Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P39654 | cf. EC 1.13.11.31, EC 1.13.11.12 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cornea | - |
Mus musculus | - |
eosinophil | eosinophils are the major cell type expressing 12/15-LOX during the corneal wound healing process | Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | eosinophils are the major cell type expressing 12/15-LOX during the corneal wound healing process. Eosinophils are recruited into the conjunctiva after corneal epithelium wounding, and eosinophil-deficient and/or eosinophil-specific 12/15-LOX knockout mice show delayed corneal wound healing compared with wild-type mice. A series of 12/15-LOX-derived mediators are significantly decreased in eosinophil-deficient mice and topical application of 17-hydroxydocosahexaenoic acid restores the phenotype | Mus musculus |